Tag 45 Ingredients Explained + How to Use

By Katarina V.| Last updated on March 6, 2024
tag 45 numbing gel explained
⏱️ 6 min read

Tag #45 is one of the most popular pain stoppers on the PMU market, and for a good reason.

It’s both safe and effective, and its formula helps reduce swelling and bleeding, making the tattooing process smoother and easier. But what’s exactly inside the well-known green bottle?

In this short guide, we’ll break down the key Tag #45 ingredients and provide insights on how to use this numbing gel safely and with maximum effectiveness. Read on!

Tag 45 Ingredients

TAG #45 is a numbing powerhouse that features a combination of carefully selected ingredients:

  • 4% lidocaine
  • 0.04% epinephrine.

Each of the listed numbing agents has its own special benefits that play an important role in the overall efficacy of the product.

tag 45 ingredients


TAG #45 contains no tetracaine, which may pose certain risks and side effects. The absence of Tetracaine underscores TAG #45’s commitment to safety and reliability during PMU procedures.

Where Can I Get Tag 45?

You can get Tag #45 on PMUHub Shop!

You can be 100% sure that our product is authentic because we source all our products directly from the manufacturer.

On PMUHub you can also find a wide range of top-quality pain stoppers that you can use before, during, and after your PMU treatments.

Check out the full list of our numbing products here!

Now, let’s take a closer look at what the Tag 45 ingredients actually are, how they work and when you should use them:

What Is Lidocaine?

If you’ve ever had a tooth filled in at the dentist’s, then you’ve probably experienced the wonders of lidocaine yourself — you just didn’t know it.

Lidocaine is a local anesthetic agent often used in both medical and esthetic procedures for pain management. It is super safe and widely recognized for its exceptional numbing properties.

At the 4% concentration in Tag #45, it numbs the targeted area in less than a minute and can last 1-2 hours.

These effects can be extended with the help of adrenaline — an ingredient also known as epinephrine, which also can be found in Tag #45.

Epinephrine slows down the absorption of lidocaine, which makes it last even longer when used in PMU procedures.

What Is Epinephrine?

If you suffer from allergies, then you must have heard of epinephrine — because this is the “Epi” part in the phrase “EpiPen”.

Epinephrine is just a medical term for adrenaline — a hormone with the primary function of preparing our bodies for a “fight or flight” response during times of stress or trauma.

What does this trauma have to do with a simple brow tattoo or lip blush?

Well, your clients might be totally comfortable with the treatment, but their skin isn’t exactly happy being stretched and poked with tiny needles over and over again.

Although adrenalin isn’t a numbing agent, it can help reduce pain sensitivity during PMU treatments, because it has vasoconstrictive properties.

It constricts the blood vessels, prevents excessive bleeding, and slows down the absorption at the application site.

At the 0.04% concentration, epinephrine adds an extra layer of effectiveness to TAG #45, making it work better and longer.

How Does Tag 45 Work?

Tag #45 works by producing temporary loss of sensation in the skin and surrounding tissues after application.

It achieves this by blocking the nerves from sending pain signals to the brain.

Basically, lidocaine closes the channels through which pain signals are transmitted, so your client can relax and enjoy their painless PMU treatment.

At the same time, epinephrine tightens the blood vessels in the skin and reduces any bleeding and swelling, which gives you more control over the tattooing process.

How to Use Tag 45?

Tag #45 is designed for external use only, so you should apply it to broken skin with a suitable sterile applicator. This is important because it won’t work on intact skin.

Remember to always clean the area first and ensure that the skin is completely dry before applying the numbing gel.

Then, apply a thin layer of Tag #45 numbing gel onto the skin and give it 2-5 minutes to start working.

During this time, lidocaine will kick in and block the nerves that convey pain sensations. Once the numbing effect is achieved, remove the excess product.

When Can I Use Tag 45?

According to the manufacturer’s notes, you can use Tag #45 for a wide range of permanent makeup treatments including:

  • Eyebrows
  • Lip blush
  • Permanent eyeliner
  • Areola tattoos

This numbing gel is super safe and it sits well on the skin without sliding, so you should be able to apply it easily regardless of your client’s chosen treatment.

tag 45 numbing gel tips and tricks

When to Avoid Using Tag 45?

Only if your client has had a history of reactions with any of the ingredients or has a reaction to the patch test, or if there’s any contraindication involved.

Otherwise, there’s no need to be in doubt here because Tag #45 numbing gel has a universal formula you can use for full-body tattooing.

So, if you’re a versatile PMU artist and you want a pain stopper that can keep up with you, Tag #45 is your new numbing BFF.

Are There Any Side Effects to Tag 45?

Tag #45 is generally considered one of the safest numbing products on the PMU market.

It belongs to the range of PainStoppers (also known as UnitDose topicals) developed by an anesthesiology specialist Dr. Linda Dixon, whose work focuses on the improvement of PMU techniques and products.

Dr. Dixon’s formulas are recognized as 100% safe and reliable, but there are some side effects you should be aware of.

It happens very rarely, but your clients might experience temporary skin irritation, heightened sensitivity, or delayed post-treatment swelling.

In more serious cases, different allergic reactions are possible, such as rash or itching.

To avoid these risks, here are some rules you should always follow:

  • Avoid contact with the eyes.
  • Do not use the product in large quantities.
  • Apply the product gently over the raw or blistered skin.
  • Do not use the product on clients with an allergy to lidocaine or epinephrine.
  • Do not use the product on clients with a history of liver disease.
  • Do not use the product on clients who are pregnant or breastfeeding.

Also, it’s a good idea to take some time to study your numbing products and their ingredients, so you can educate your clients and feel more comfortable working with these anesthetics.

Here’s where you can find everything about PMU numbing agents and more.

Are There Any Legal Limits Regarding Tag 45?

Depends on your location. The regulations concerning topical anesthetics can vary between states, countries, and even regions.

For example, the US regulations allow a maximum percentage of 5% lidocaine for topical numbing – and Tag #45 is within this limit with its 4% lidocaine concentration.

However, if you’re a UK-based PMU artist, you might find that Tag #45 and other similar numbing products have no safety clearance due to their high doses of anesthetics.

Also, you might find your choice limited to products containing only a single numbing agent, which is the case with Texas-based artists.

To avoid potential problems, contact the local health authorities and verify the specific legal requirements and restrictions related to Tag #45 or any other topical anesthetics you plan to use.

How Can You Tell If a Tag 45 Is Real?

If you’ve purchased Tag #45 from an unauthorized seller or supplier, there’s a fair chance that your product is fake.

In that case, these are a few steps that you can take to check if Tag #45 is real:

Step 1:

Check for a small sticker in the top left corner of the TAG #45 label.

You should find four small black dots over the “4%” inside a starburst shape.

If this sticker is missing or looks different than it should, then your product may be fake.

Step 2:

Scan the barcode on the back of the bottle.

This way you can verify the authenticity of the product by checking its unique code against the manufacturer’s database.

Step 3:

Examine the packaging.

Look for any signs of tampering or damage because fake products often come with suspicious or altered packaging.

Tag #45: Main Takeaways

Overall, Tag #45 has a very simple formula featuring only two active agents — lidocaine and epinephrine.

In combination, these two ingredients not only block the pain but also reduce bleeding and swelling.

The product is easy to apply and it works almost instantly, allowing your clients to fully enjoy their PMU treatment.

So, if you haven’t tried Tag #45 yet, it’s time to give it a go!

Just make sure you verify with the local authorities that your usage complies with relevant laws and regulations.



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